Fibrin, an insoluble protein derived from the soluble protein fibrinogen, during the process of blood clotting stops bleeding by forming a mesh around the wound. It is an essential component for the remedial process. The levels of fibrin are controlled by the natural enzymes adduce in our body. Whatever deviation in maintaining the balance might cause a disorder in the body chemistry. If the amount of fibrin present in the body is low it can cause hemorrhages due to excess bleeding while an excess of Fibrin can result in multiple disorders and malfunctioning. Here are some effects concerning the presence concerning too much fibrin in the system as well as very little.
WHAT IS FIBRIN?
Fibrin is an insoluble protein generated during the coagulation system from fibrinogen with help like thrombokinase (an enzyme). It plays an important role in hemotasis et al platelet activation.
Coagulation is a process which ceases the flow of blood from a damaged vessel. It begins when the inner lining of a blood vessel is damaged. Exposure of the blood to proteins produces two components: fibrinogen (a blood protein) and platelets. As soon as a person is injured the process concerning blocking begins by accumulation of platelets on the opening of the wound. Fibrinogen, a soluble protein is converted to its insoluble form fibrin through a series of chemical reactions. The fibrin strands beef the platelet covering and yet stop the blood flow.
EFFECTS OF EXCESS FIBRIN
Blood Receptacle Blockage
A large amount about fibrin now in the blood results in clot-formation in the blood vessels. Due to this the narrow passageway of the arteries, veins and capillaries are totally or partially blocked thus creating misbalance in race supply to the cardiological or part other body part. When there is a diminished supply of blood and oxygen to the heart for a long period it ultimately leads to cardiac arrest repeatedly resulting in death. Blocking the poisoning supply to the brain can cause the Alzheimer’s disease. Since the diameter of the blood vessels becomes extremely narrow due to the clot formation, there is also a significant rise in blood pressure.
Fibrin generated inflammation is a common syndrome amidst persons having excess regarding the unresolved meat in their blood. As a side-effect of accumulation of supernumerary fibrin in our body, aging organs tend to shrink and harden causing pain and swelling. Cell adhesion is also characterized by inflammation of a particular part.
Due to inflammation and scarce tissue development as well as cell adhesion, arthritis is seen in electorate with a high fibrin level. This is characterized by joint stiffness, limited movement due to inflammatory pain and soft tissue changes.
EFFECTS OF LOW FIBRIN LEVEL
This insoluble protein present in scarce amounts leads to excessive coagulate loss if injured. An extensive quantity of blood ullage leads to hemorrhages. Hemophiliacs when injured show this trait. Some recent researches show that fibrin does not play much role as a coagulant but the absence of it container cause serious damage.